Research

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Neurogenetics and Neurogenomic imaging

alzheimers

Mentors and collaborators: Peter Ren, Yosuke Tanigawa, David A. Bennett, Manolis Kellis, Xiaowei Zhuang

I develop statistical genetics and genome-scale imaging approaches to understand the human brain.

Publications and abstracts

  1. Li WF, Ren P, Liu S, Wang CY, Zheng P, Ren B, Lein ES, Zhuang X. Comparative analysis of 3D-genome organization in the human and mouse brain. Poster presented at: Harvard/MIT MD-PhD Program Retreat; September 2025; Cape Cod, MA.
  2. Ren P, Li WF, Wang CY, Liu S, Bintu B, Zheng P, Su JH, Kinrot S, Mateo LJ, Boetigger A, Ren B, Zhuang X. Tracing Chromosomes in Cells with Fluorescence Imaging. Poster presented at: Harvard Chemistry and Chemical Biology Graduate Open House; September 2025; Cambridge, MA.
  3. Liu Z, Zhang S, James BT, Galani K, Mangan RJ, Fass SB, Liang C, Wagle MM, Boix CA, Tanigawa Y, Yun S, Sung Y, Xiong X, Sun N, Hou L, Wohlwend M, Qiu M, Han X, Xiong L, Preka E, Huang L, Li WF, Ho LL, Grayson A, Mantero J, Kozlenkov A, Mathys H, Chen T, Dracheva S, Bennett DA, Tsai LH, Kellis M. Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience. Cell. 2025;188(18):4980-5002.
  4. Tian X, Fabiha T, Li WF, Dey KK, Kellis M, Tanigawa Y. Integrative polygenic score modeling with tissue-specific annotation improves polygenic scores transferability. Talk presented at: American Society of Human Genetics; November 2024; Denver, CO. (PDF)
  5. Tanigawa Y, Sun N, Li WF, Boix CA, Galani K, Mathys H, Bennett DA, Tsai LH, Kellis M. Multi-polygenic score model informs the genetic basis of heterogeneity in Alzheimer’s disease. Talk presented at: Alzheimer’s Association International Conference; July 2023; Amsterdam, Netherlands. (PDF)
  6. Li WF, Tanigawa Y, Kellis M. Polygenic dissection of phenotypic heterogeneity in Alzheimer’s disease. Poster presented at: Broad Institute Scientific Retreat; December 2022; Boston, MA. (PDF)
  7. Tanigawa Y, Sun N, Li WF, von Maydell D, Boix CA, Akay LA, Galani K, Mathys H, Bennett DA, Tsai LH, Kellis M. Single-cell transcriptional hallmarks and individual subtyping for Alzheimer’s Disease across 430 participants. Talk presented at: Society for Neuroscience; November 2022; Washington, DC. (PDF)

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Nanophotonic imaging

end_to_end

Mentors and collaborators: Gaurav Arya, Charles Roques-Carmes, Zin Lin, Steven G. Johnson, Marin Soljačić

Through end-to-end optimization, I design nanoscale structures to enhance traditional imaging components, such as lenses in optical imaging and scintillators in X-ray imaging.

Publications and abstracts

  1. Soljačić M, Roques-Carmes C, Rivera N, Lin Z, Li WF, inventors; Massachusetts Institute of Technology, assignee. Nanophotonic Scintillators for High-Energy Particles Detection, Imaging, and Spectroscopy. U.S. Patent Application 18/701,792. May 2025.
  2. Arya G, Li WF, Roques-Carmes C, Soljačić M, Johnson SG, Lin Z. End-to-end Optimization of Metasurfaces for Imaging with Compressed Sensing. ACS Photonics. 2024;11(5):2077-2087. (PDF)
  3. Li WF, Arya G, Roques-Carmes C, Lin Z, Johnson SG, Soljačić M. Transcending shift-invariance in the paraxial regime via end-to-end inverse design of freeform nanophotonics. Optics Express. 2023;31(15):24260-24272. Editors’ Pick. (PDF)
  4. Li WF, Roques-Carmes C, Lin Z, Johnson SG, Soljačić M. X-ray Spectroscopy With End-to-End Optimized Nanophotonic Scintillators. Talk presented at: Conference on Lasers and Electro-Optics; May 2023; San Jose, CA. (PDF)
  5. Li WF, Arya G, Roques-Carmes C, Lin Z, Johnson SG, Soljačić M. Transcending shift-invariance in the paraxial regime via end-to-end inverse design of freeform nanophotonics. Talk presented at: MIT PRISM Undergraduate Physics Conference; September 2, 2022; Cambridge, MA.
  6. Li WF, Arya G, Roques-Carmes C, Lin Z, Johnson SG, Soljačić M. Angular and Spectral Sparse Sensing With End-to-End Optimized Nanophotonics. Talk presented at: Conference on Lasers and Electro-Optics; May 2022; San Jose, CA. (PDF)
  7. Lin Z, Arya G, Li WF, Roques-Carmes C, Pestourie R, Li Z, Capasso F, Soljačić M, Johnson SG. End-to-end Nanophotonics Inverse Design for Computational Imaging. Talk presented at: Conference on Lasers and Electro-Optics; May 2022; San Jose, CA. (PDF)

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